Distinct types of life events interact with 5-HTTLPR in the development of depressive symptoms in an age- dependent manner
نویسنده
چکیده
Semmelweis University, Department of Psychiatry and Psychotherapy and MTA-SE Neuropsychopharmacology and Neurochemistry Research Group of the Hungarian Academy of Sciences, Budapest, Hungary Semmelweis University, Department of Pharmacodynamics and MTA-SE Neuropsychopharmacology and Neurochemistry Research Group of the Hungarian Academy of Sciences, Budapest, Hungary University of Manchester, Neuroscience and Psychiatry UnitInstitute of Brain Behaviour and Mental Health, Manchester, United Kingdom Semmelweis University, Department of Pharmacodynamics and MTA-SE-NAP B Genetic Brain Imaging Migraine Research Group of the Hungarian Academy of Sciences, Budapest, Hungary
منابع مشابه
Financial difficulties but not other types of recent negative life events show strong interactions with 5-HTTLPR genotype in the development of depressive symptoms
Several studies indicate that 5-HTTLPR mediates the effect of childhood adversity in the development of depression, while results are contradictory for recent negative life events. For childhood adversity the interaction with genotype is strongest for sexual abuse, but not for other types of childhood maltreatment; however, possible interactions with specific recent life events have not been in...
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Psychosocial stress, including stress resulting from racial discrimination (RD), has been associated with elevated depressive symptoms. However, individuals vary in their reactivity to stress, with some variability resulting from genetic differences. Specifically, genetic variation within the linked promoter region of the serotonin transporter gene (5-HTTLPR) is related to heightened reactivity...
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BACKGROUND Previous studies of the interaction between a functional polymorphism in the serotonin transporter gene-linked promoter region (5-HTTLPR) and stress in anxiety-related phenotypes have produced inconsistent results. The aim of the current study was to examine the effect of the 5-HTTLPR × stress interaction on anxiety symptoms in Chinese adolescents. METHODS A total of 651 healthy ad...
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BACKGROUND Recent meta-analyses have raised concerns about the replicability of gene × environment interactions involving the serotonin transporter gene (5-HTTLPR) in moderating the associations between adverse life events and mental disorders. AIMS To use data gathered over the course of a 30-year longitudinal study of a New Zealand birth cohort to test the hypothesis that the presence of sh...
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Research suggests that a polymorphism in the promoter region of the serotonin transporter promoter (5-HTTLPR) interacts with stressful life events to predict depressive onset, with short (s) allele presence associated with greater susceptibility to stressors. However, this research has not considered that depressed individuals often actively generate stressful contexts. Furthermore, little is k...
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